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Disconnection of the hippocampus and amygdala in MS

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Conclusion: The concurrent increased functional connections and demyelination-related structural disconnectivity between the hippocampus or amygdala and other regions in RRMS suggest that the functional–structural relationships require further investigation. Read this original research and sign up to receive Neuropsychiatric Disease and Treatment journal here: http://www.dovepress.com/articles.php?article_id=22669
Figure 5 The correlation between structural/functional connectivity indices (y axis) and lesion load (x axis) in RR MS patients.

Figure 5 The correlation between structural/functional connectivity indices (y axis) and lesion load (x axis) in RR MS patients.

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Figure S2 Brain regions with significant differences (P,0.05, corrected) in rsFC patterns for all seed regions between the RR MS patients and the HCHCs.

Figure S2 Brain regions with significant differences (P,0.05, corrected) in rsFC patterns for all seed regions between the RR MS patients and the HCHCs.

Figure S3 An example of the relationship between functional connectivity strength (FCS ) and structural connectivity measures in other thresholds (0.05, 0.10, 0.15, 0.20, 0.25, and 0.30) of probabilistic tractography.

Figure S3 An example of the relationship between functional connectivity strength (FCS ) and structural connectivity measures in other thresholds (0.05, 0.10, 0.15, 0.20, 0.25, and 0.30) of probabilistic tractography.

Figure 3 An example of the white-matter fibers of the amygdala and hippocampus detected by probabilistic tractography.

Figure 3 An example of the white-matter fibers of the amygdala and hippocampus detected by probabilistic tractography.

Figure 4 Correlation between SC and FC in the amygdala or hippocampus in the RR MS.

Figure 4 Correlation between SC and FC in the amygdala or hippocampus in the RR MS.

Figure S1 Statistical significance (color-coded t-score) of the rsFC patterns for the amygdala and hippocampus in both the HC and the RR MS groups.

Figure S1 Statistical significance (color-coded t-score) of the rsFC patterns for the amygdala and hippocampus in both the HC and the RR MS groups.

Figure 1 A flowchart of the calculation of the connectivity of the amygdala and hippocampus.

Figure 1 A flowchart of the calculation of the connectivity of the amygdala and hippocampus.

Figure 2 A set of connectivity matrices of functional and structural analyses of the amygdala and hippocampus in the RR MS and healthy control (HC ) groups.

Figure 2 A set of connectivity matrices of functional and structural analyses of the amygdala and hippocampus in the RR MS and healthy control (HC ) groups.